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Thanks Vasiliy, I wonder if it was Sacket who was kidding then because it was not my point of view. i just quoted from his narrative. Perhaps Amy, Ben or Neal may like to comment further on this 'bias' issue? best, rb On Mon, Jun 13, 2016 at 11:22 AM, vasiliy vlassov <[log in to unmask]> wrote: > Dear RB, > I am not quite sure that you are just kidding, so: this is not the example > of the power of placebo, but the example of the self-selection bias. > vvv > > On 2016-06-12 14:39, Rakesh Biswas wrote: > >> In light of the earlier comments on the placebo effect (deemed >> insignificant) I shall be grateful to the group to understand further >> this quote from a narrative by Sacket linked below, "the >> hero-statistician of the trial, Paul Canner, carried out a similar >> analysis for participants who did and didn’t take their placebos as >> instructed. He showed an even stronger association between compliance >> effect and mortality (0.151 vs. 0.282; Relative Risk Ratio=46%; z=-8.12; >> P=0.00000000000000047), implying that one premature death would be >> prevented for every 10 patients who took their placebo faithfully!" >> More: >> http://www.jameslindlibrary.org/articles/why-did-i-become-a-clinician-trialist/ >> >> best, >> >> rb >> Dept of Medicine, >> LN Medical College, Bhopal >> >> >> > Vasiliy V. Vlassov, MD > President, Society for Evidence Based Medicine (osdm.org) > e-mail: vlassov[a t]cochrane.ru > snail mail: P.O.Box 13 Moscow 109451 Russia > Phone Russia +7(965)2511021 > > Подпишись на новости на osdm.org > > -- > THANK YOU for deleting my e-mail address , any other addresses, and any > personal information, from this e-mail, if you plan to forward it. Also, > thank you for using “Bcc” instead of “To” and “Cc“ when initiating both > individual and group e-mails. These extra actions on your part help to > prevent spammers and hackers from obtaining addresses and thus help > prevent the proliferation of spam. >