Scientists, be part of Cedars-Sinai’s commitment to Precision Health through an exciting opportunity at the Cedars-Sinai IBD Drug Discovery and Development Unit (IBD³). The mission of the IBD³ unit is to use personalized medicine approaches to predict the success of current and future therapeutics for inflammatory bowel diseases. The IBD³ program is uniquely structured to join academic science with industry partners to discover and validate new therapeutic targets, accelerate drug development through patient stratification, and rescue and repurpose failed drugs by identifying drug responsive patient populations.

The IBD³ unit is seeking a mission-focused Project Scientist, with expertise in the development of protein expression and purification strategies to support ongoing drug discovery and development needs.  Under the leadership of the IBD³ unit Director, the Project Scientist will independently implement a variety of expression systems including e.coli, mammalian and baculovirus cell culture.

The Project Scientist will provide hands-on expertise in construct design, protein expression and purification.  They will have proven experience in difficult-to-express and purify proteins such as membrane proteins, enzymes and Fc-fusions for biologics and X-ray crystallography. 

Independently and as part of the IBD³ team, the Project Scientist will use protein biochemistry and structural biology knowledge to outline strategies and workflows for optimization of protein production needs.  They will support assay development in line with the project needs within the drug development group. Where necessary, the Project Scientist will manage collaborations with CRO’s for protein production, structure determination and manufacturing of proteins and protein therapeutics to ensure timelines, budgets and project goals are met.  The Project Scientist will work closely with computational scientists for structure-function studies and structure-based drug design. 

The Project Scientist will have exceptional skills in research methodology, clear communication, accurate documentation, SOP development and adherence, technical report preparation and data presentation.  

The Project Scientist will supervise and train laboratory staff in assay development, protein expression and production where needed and will maintain compliance and safety standards.  The Project Scientist will be a team player and will effectively interact with groups outside the drug development unit in order to drive timelines and achieve IBD³ unit goals.