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Thanks David. I really can see the BINARY.setup. Will you please tell me the command to run the BINARY.setup? Smith ÔÚ 2016-04-03 23:51:14£¬"David Waterman" <[log in to unmask]> дµÀ£º Dear Smith, If you downloaded and unpacked one of the large bundles then you need to run BINARY.setup, found inside the directory ccp4-7.0/, which will create the setup files in bin/ If however you install using the recommended package manager this step is automatically done for you. Best wishes -- David On 3 April 2016 at 16:07, Smith Liu <[log in to unmask]> wrote: Dear All, For the newly installed CCP4 7.0, there is really no ccp4.setup-csh and ccp4.setup-sh. I have just installed the CCP4 7.0 with and without SHELX, neither can find the ccp4.setup-csh and ccp4.setup-sh? Is any bug? I am looking forward to getting your reply. Smith At 2016-04-03 22:06:28, "Kevin Battaile" <[log in to unmask]> wrote: Hi Smith, That file is in the bin directory. It should be ccp4-7.0/bin/ccp4.setup-sh or ccp4.setup-csh Thanks, -Kevin On Sun, Apr 3, 2016 at 6:02 AM, Smith Liu <[log in to unmask]> wrote: Dear All, For CCP4 6.5, in order to use CCP4 in a directory we can do "source /path to cc4-6.5/bin/ccp4.setup-csh'. But for CCP 7.0, it seems there is no ccp4.setup-csh in the CCP4 bin directory. Will you please tell me how to source CCP4 in a directory for use the CCP4 programmes? Smith