Dear Anderson,the design is followinggroup score age1 231,2 13,31 125,4 10,51 220,2 12,5...contrast0 1 00 -1 0and I would like to test whether there is a relationship between DTI measures and demean score.Looking forward to your response.BestAlena2016-03-17 3:24 GMT-05:00 Anderson M. Winkler <[log in to unmask]>:Hi Alena,Depends on how the design was coded and if it includes an intercept. Could you show the design?All the best,AndersonOn 16 March 2016 at 16:06, Alena Piovar <[log in to unmask]> wrote:Dear FSL users,I have a question regarding -D option in randomise is it necessary to adjust it to examine differences between two population adjusted for age as a covariate if the covariate was demeaned by hand (actual values minus mean of age)?Looking forward to your responseBestAlena