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Hi Nora, you will be on the safer side by choosing that option. However, my impression is that there is only minor impact of different regularizations on affine registration. It is rather important to define the origin if spatial registration will fail. Best, Christian On Thu, 25 Feb 2016 09:28:18 +0000, Raschle, Nora <[log in to unmask]> wrote: >Hi ?experts > > >I have a younger sample of participants and did run the TOM8 toolbox to create tissue priors. I was planning to implement these in cat12. As described in the manual the TPMs can be selected during affine registration as a first preprocessing step. I was wondering whether it is also recommended to switch the ICBM space template to the T1 average template created by TOM under "Options for initial SPM12 affine registration">"Affine Registration"? > > >Thanks a lot for a recommendation! >Nora >