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Dera all, I am trying to set up a paired t-test (VBM) with a total of 66 pairs. In addition I want to model an interaction with a categorical variable that does not differ within pairs (i.e. group status 0 and 1 for 43 vs. 23 pairs). I would like to determine whether within pair differences are affected by group status. However I'm slightly puzzled by the design matrix (attached) and how to set up the contrasts to answer my question. Any help is highly appreciated. Thanks in advance & cheers Chris