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Dear Members, I am working with a multi-domain protein with 4 domains. I have two structures, one apo and the other in complex with small molecule inhibitor. When I superposed the two structures in pymol, I can clearly see that domain 1 has been rotated compare to the apo structure. Can anyone suggest a tool to calculate the domain rotation? It might not be pure rotation. Also what would be the best way to calculate the change in domain-interface area as a result of complex formation with small molecule. Any suggestion would be very helpful. Best regards, Raja