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Hi Iris, If you could post design and contrasts, tell what kind of data you have (TBSS, RSNs, task FMRI, etc), and tell exactly how PALM is being invoked maybe we could help. Btw, the 42 contrasts are the same as having 42 hypotheses on the same data. Do you really need all of them? Regardless, we should have some methods available soon that will increase speed. Hopefully it will take less than 500 hours until it's released, though, well, let's not make promises. Cheers, Anderson On 15 December 2015 at 13:04, SUBSCRIBE FSL IrisL < [log in to unmask]> wrote: > Hi Anderson, Thanks for your reply. I set up the analysis. It is going to > take quite some time; estimation is 500 hours because of 42 contrasts > (t-tests) and 5000 permutations. Do you know if there is any way to speed > up the process? Many thanks, Iris