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I too would like some clarification on this. It's my understanding that the role of pre-whitening time series is to reduce the inflated cross-correlations between series which each have auto-correlation structure. The pre-whitening reduces or removes that auto-correlation structure providing more confidence in the reliability of "significant" cross-correlation findings. That role I had thought would apply to resting recordings as well as task recordings. Am I missing something? From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Stephen Smith Sent: Friday, November 20, 2015 1:26 PM To: [log in to unmask] Subject: Re: [FSL] Prewhitening in resting-state fMRI sorry - no - I'm not aware of any reason why it is necessary to do the whitening. cheers On 20 Nov 2015, at 18:15, Andrew Song <[log in to unmask]<mailto:[log in to unmask]>> wrote: Thank you for the quick response. Just to make sure that I understand it correctly, there is no reason NOT to do prewhitening in resting-state studies? Thank you, --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Head of Analysis, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask]<mailto:[log in to unmask]> http://www.fmrib.ox.ac.uk/~steve --------------------------------------------------------------------------- Stop the cultural destruction of Tibet<http://smithinks.net>