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Hi Feng, You can use the command Glm (or Glm_gui in the Mac) to create this or any other design. See some examples in the manual, in particular this one: http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/GLM#Two-Group_Difference_Adjusted_for_Covariate All the best, Anderson On 1 November 2015 at 08:19, chenhf_uestc <[log in to unmask]> wrote: > Dear FSL experts, > > Now, I want to perform multiple comparison correction on my TBSS result. > In the online manual, it states > > cd ../statsdesign_ttest2 design 7 11 > > In my case, I want to regress the age and gender effect. However, the > function design_ttest2 may not achieve the goal (I can not add the > covariate in this function). > > Could somebody give me some suggestions? > > Any help would be great appreciate! > > Best, > Feng > > 2015-11-01 > ------------------------------ > chenhf_uestc >