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Or possibly a transcription factor? Depending on scaling, that looks like it might be a pretty good mimic of the major groove of dsDNA. From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Tristan Croll Sent: Thursday, 26 November 2015 2:21 PM To: [log in to unmask] Subject: Re: [ccp4bb] [Off-Topic] groove sandwiched by negatively charged patches Collagen? From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Tianlong Zhang Sent: Thursday, 26 November 2015 2:09 PM To: [log in to unmask]<mailto:[log in to unmask]> Subject: [ccp4bb] [Off-Topic] groove sandwiched by negatively charged patches Hi all, Recently we determined a structure of a human protein with unknown function. We observed an uncharged groove (about 20A x 20A) sandwiched by two negatively charged patches (see the attached figure). Can anyone provide any information about the potential binding partner for this groove? All suggestions are welcome. Best regards, Tianlong ________________________________ Tianlong Zhang