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Dear Martin,


Sorry about the delay. I haven’t come across that option; John may be able to comment. 

A classical way of integrating ROI analyses with SPM (benefiting from the intuitive design matrix etc.) is Matthew Brett’s MarsBar, have you tried that?

However, if you are interested in time course modelling of your original data, staying within PMOD may be the better option. There are lots of details to be thought of (e.g. how exactly frame length is coded & integrated, weighting, etc.).

Hope this helps,

All the best,

A

-----------------------------------------
Alexander Hammers, MD PhD

Professor (Honorary Consultant) of Imaging and Neuroscience
Head of PET Imaging Centre
Division of Imaging Sciences and Biomedical Engineering
King's College London
St Thomas' Hospital, London

Telephone +44-(0)20 7188 8364 (PA Viviane Schroeder)
Email [log in to unmask]





On 14 Sep 2015, at 06:06, Martin Juneja <[log in to unmask]> wrote:

Dear Dr. Hammers,

Thanks a lot for your reply and for the suggestions. That's really helpful.

Also, I have another quick question. I found in SPM that when we display dynamic contrast enhancement MRI (DCE-MRI) data in SPM and then overlay with anatomical image, there is an option (when we right click on the image) to launch ROI in ROI tool, which allows to import ROI image (please see attached screen shot just to make it more clear).

If we do that, then:
- Is there any way to extract TAC from DCE-MRI data after importing the ROI using ROI tool ?

I am able to successfully import ROI in this way and I guess there should be some way to extract TAC in this way but somehow I couldn't find the option to extract.

Any help would be really appreciated.

Thanks much.
Martin

On Sun, Sep 13, 2015 at 10:24 AM, Alexander Hammers <[log in to unmask]> wrote:
Dear Martin,


SPM is not really set up to extract TACs from PET. It is highly likely that you would be much better off importing your MRI into PMOD and staying in that environment for VOI analyses.

You could, for example, define your VOIs on MRI within PMOD using the PNeuro module which is set up to do exactly that. You can also coregister your MRI & regions to PET and then extract TACs.

Of course if you were to analyze your paramatric maps created in e.g. PMOD at the voxel-level at some stage, SPM would be just the ticket!

Hope this helps,

All the best,

A
-----------------------------------------
Alexander Hammers, MD PhD

Professor (Honorary Consultant) of Imaging and Neuroscience
Head of PET Imaging Centre
Division of Imaging Sciences and Biomedical Engineering
King's College London
St Thomas' Hospital, London

Telephone +44-(0)20 7188 8364 (PA Viviane Schroeder)
Email [log in to unmask]


On 11 Sep 2015, at 21:13, Martin Juneja <[log in to unmask]> wrote:

Dear SPM community,

I have preprocessed PET scan data for some subjects and defined few VOIs for each subject (in .voi format) using PMod. On the other hand, I also preprocessed MRI data (realignment and co-registration steps), of same subjects using SPM12.

I was wondering if there is any way I can use the VOIs I defined in PMod and import those for MRI preprocessed data to get time-activity curve? If yes, could some one please suggest me few toolboxes which would be helpful to do the job.

Thanks a lot.
Martin


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