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Dear Niels, You are great!! Thanks a lot Jon Hi - there isn't a special flag needed. It's part of the SIENAX pipeline itself. This is actually how the absolute volumes (derived from the FAST segmentation) are turned into normalized volumes. The VSCALING value is reported in the report.sienax file but not report.html. You can get them in batch via some basic shell scripting (or you can just open the report.sienax files with text editor). However, if you're more comfortable with the report.html file (or you already have your SIENAX values extracted), you can obtain the scaling parameter by simply dividing a normalized value by its corresponding absolute value (e.g. normalized brain volume / absolute brain volume). Hope this helps - good luck. On Sun, Oct 25, 2015 at 4:24 PM, Jon Anderson <[log in to unmask]> wrote: Dear niels, I highly appreciate your respnonse. Kindly what do you mean by " VSCALING parameter". Which flag I should use as an option in SIENAX? Thanks a lot! Hi - the closes thing you'll get is the VSCALING parameter from SIENAX. This is a normalization factor to corrected for head size. It's derived from a skull-constrained registration of a given brain to standard space. This value is inversely related to head size. So it's not circumference, but maybe it will suit your needs. On Sun, Oct 25, 2015 at 3:57 PM, Jon Anderson <[log in to unmask]> wrote: Dear FSL experts, I want to inquire if there is any tool (script) or method in FSL that can help to calculate the head circumference from MPRAGE ? Thanks for any advice! Jon -- Niels Bergsland Integration Director Buffalo Neuroimaging Analysis Center 100 High St. Buffalo NY 14203 [log in to unmask] -- Niels Bergsland Integration Director Buffalo Neuroimaging Analysis Center 100 High St. Buffalo NY 14203 [log in to unmask]