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2 Postdoctoral Research Positions: Tools and Reagents for Next Generation Inhibitor Discovery in Peptidoglycan biosynthesis with Dr David I Roper at the University of Warwick. Applications are invited for two enthusiastic postdoctoral research scientists to join a research group at the School of Life Sciences, University of Warwick, UK supervised by a team headed by Dr David I Roper. The project, which has been funded by a BBSRC-LINK grant award with Merck Pharmaceuticals, focuses on acquiring specific structural and biochemical data relevant to drug discovery and multi-targeting bacterial cell wall biosynthetic glycoslytransferases including penicillin binding proteins. The successful applicants will be required to work individually but also within a wider team focussing on bacterial cell wall biosynthesis as a target for novel antimicrobial discovery. Post 1: Research Fellow in Structural Biology You will have a recently awarded PhD in a relevant subject and a strong background in experimental biochemistry, molecular cloning, protein expression, purification, and X-ray crystallography. Specifically you will work within a team investigating glycosyltransferase enzymes including Penicillin Binding Proteins (PBPs) required for bacterial cell wall biosynthesis in a joint project with Merck Pharmaceuticals and will involve the use probe compounds to explore GT enzyme mechanism, GT co-crystal structures with inhibitors/ fragments and biochemical characterization. For further details and applications please go to Research Fellow - Structural Biology (76915-105) . Post 2: Research fellow in Enzymology and assay development You will have a recently awarded PhD in a relevant subject and a strong background in experimental biochemistry, molecular cloning, protein expression, purification, assay development, chemical biology and microbiology. Specifically you will work within a team investigating glycosyltransferase (GT) enzymes including Penicillin Binding Proteins (PBPs) required for bacterial cell wall biosynthesis in a joint project with Merck Pharmaceuticals and will involve the development of tools and reagents for GT study, including quantitative assays suited to high-throughput screening and bespoke substrate mimetics. For further details and applications please go to Research Fellow - Enzymology and Assay Development (76914-105). These posts will involve the successful applicants in discussion and development of potential inhibitor compounds leading to further translational research and opportunities. Both positions are available for up to 24 months and will involve interaction with outside academic medicinal chemistry and pharma industry colleagues. The posts may also involve interaction with scientists at, and short periods of secondment to, the Research complex at Harwell (http://www.rc-harwell.ac.uk/diamond) and Diamond synchrotron ( http://www.diamond.ac.uk/Home.html) in Oxfordshire. The School of Life Sciences at Warwick is equipped with state-of-the-art protein expression and purification apparatus, including high-throughput facilities for crystallisation and visualisation as well as in-house x-ray generators with image plate detectors and regular synchrotron access in the UK and abroad. The wider laboratory is very well equipped with microbiological, biochemical and biophysical infrastructure and the successful applicants will join a wider team of highly motivated scientists working on a range of antimicrobial discovery and resistance projects. The successful applicants must be able to start between January 1st to March 1st 2016, The appointments will be for a fixed term contract for up to 24 months with salary starting from £28,695 per annum. Informal enquiries may be made to Dr David Roper; [log in to unmask]<mailto:[log in to unmask]> tel +44 (0)24 7652 8369