Dear colleagues

 

It would be interesting to get an impression of the ALT reference range used in other laboratories.

 

NICE CG165 on Diagnosis and Management of Chronic Hepatitis B, published in June 2013 (http://www.nice.org.uk/guidance/cg165/evidence/cg165-hepatitis-b-chronic-full-guideline3) makes reference to ALT a number of times, and bases important clinical decisions on “normal”, “abnormal” and “normalized” ALT levels, which they define as greater than or equal to 30 IU/L for males and greater than or equal to 19 IU/L for females

 

There is some explanation of why these cutoffs were chosen on page 159:

 

With alcohol use and obesity now so common the impact of using these ALT reference ranges on diagnostic investigations could be very significant.

 

Harmony does not appear to have agreed a cutoff for ALT, unlike other LFT.

 

If you want to reply with your cutoff only, I will collate the responses for the mailbase.

 

 

 

Regards

 

Marieke

 

Dr Marieke Jordaan

 

Consultant Chemical Pathologist

Mid-Yorkshire Trust

 

Email: [log in to unmask]

Tel: (01924) 317060 or ext 57060

PA, Diane Blakeston: (01924) 317056 or ext 57056

 

 

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