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Dear Martin, SPM is not really set up to extract TACs from PET. It is highly likely that you would be much better off importing your MRI into PMOD and staying in that environment for VOI analyses. You could, for example, define your VOIs on MRI within PMOD using the PNeuro module which is set up to do exactly that. You can also coregister your MRI & regions to PET and then extract TACs. Of course if you were to analyze your paramatric maps created in e.g. PMOD at the voxel-level at some stage, SPM would be just the ticket! Hope this helps, All the best, A ----------------------------------------- Alexander Hammers, MD PhD Professor (Honorary Consultant) of Imaging and Neuroscience Head of PET Imaging Centre Division of Imaging Sciences and Biomedical Engineering King's College London St Thomas' Hospital, London Telephone +44-(0)20 7188 8364 (PA Viviane Schroeder) Email [log in to unmask] On 11 Sep 2015, at 21:13, Martin Juneja <[log in to unmask]> wrote: > Dear SPM community, > > I have preprocessed PET scan data for some subjects and defined few VOIs for each subject (in .voi format) using PMod. On the other hand, I also preprocessed MRI data (realignment and co-registration steps), of same subjects using SPM12. > > I was wondering if there is any way I can use the VOIs I defined in PMod and import those for MRI preprocessed data to get time-activity curve? If yes, could some one please suggest me few toolboxes which would be helpful to do the job. > > Thanks a lot. > Martin