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Multi-targeting of aminoacyl tRNA synthetases: a paradigm shift in combatting AMR.
The following postdoctoral position will be available for applications from Monday September 14th for 14 days through www.jobs.ac.uk or directly from the University of Warwick with the following reference no Research Fellow (75530-095)
Applications are invited for an enthusiastic postdoctoral research scientist to join a research group at the School of Life Sciences, University of Warwick supervised by a team headed by Dr David I Roper. The project, which has been funded by a Medical Research Council Innovation award, focuses on acquiring specific structural and biochemical data relevant to multi-targeting bacterial tRNA synthetases through a novel strategy. This position is available for up to 21 months in the first instance and may involve interaction with outside academic medicinal chemistry and pharma industry colleagues. The post may also involve interaction with scientists at, and short periods of secondment to, the Research complex at Harwell (http://www.rc-harwell.ac.uk/diamond) and Diamond synchrotron (http://www.diamond.ac.uk/Home.html) in Oxfordshire, UK.
We are looking for a postdoctoral fellow with a recent Ph.D. degree in a relevant field and should have a background in biochemistry or molecular biology discovery generally. The successful applicant should have proficiency in molecular cloning, protein expression, purification, crystallization and in particular X-ray crystal structure determination. We aim to rapidly solve the structures of a number of tRNA synthetases with active site inhibitor compounds to create a library of representative structures for further inhibitor development with collaborators. The post will therefore involve the successful applicant in discussion and development of potential inhibitor compounds leading to further translational research and opportunities.
The School of Life Sciences at Warwick is equipped with state-of-the-art protein expression and purification apparatus, including high-throughput facilities
for crystallisation and visualisation as well as in-house x-ray generators with image plate detectors and regular synchrotron access in the UK and abroad. The wider laboratory is very well equipped with microbiological, biochemical and biophysical infrastructure
and the successful applicant will join a wider team of highly motivated scientists working on a range of antimicrobial discovery and resistance projects.
Dr David I Roper
Reader in Structural Biology
BBSRC-RSE Enterprise Fellow 2015-2106
School of Life Sciences,
Tel 44 (0)24 7652 8369
Fax 44 (0)24 7652 3701
email [log in to unmask]
