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Laura, One thing I would try is looking through the individual results to make sure everyone was doing the task! Even after carefully explaining what I want subjects to do, there have been times when subjects did the task for half the run and then stopped, or did not do the task at all, but occasionally pressed a button at random to keep me happy! Possibly you have an independent record of button presses or some other feedback that would help you verify that subjects were doing the task the whole time? Jim Lee On 8/18/15, Laura Bled <[log in to unmask]> wrote: > Dear SPM experts > > > I have 2 groups- patients and controls - one group (controls) very strong > activation of the amygdala, FFA and occipital cortex during a fearful task. > The second group- patients - nothing significant. Both analyses - one sided > t-test in SPM12. > > Running Two-sided t-test shows no difference ! By all logic Controls vs > Patients should have yield extensive significant results, and yet there is > nothing significant - in both directions. > > > > Could anyone help me to understand this, and how to interpret the results. I > have checked the data with ArtRepair for outliers, so nothing there to > report... > > > > THANK YOU in advance > > > Laura > > > >