Hello FSLers,

Thanks for taking the time to read this help request.  Here is my situation-

I have a sample of 17 subjects with on medication and off medication resting state data.  I’d like to use the difference of an on-meds task score and off-meds task score as covariate.  I currently have this covariate in the form of off task score minus on task score.

What I would ideally want to look at is:

1. Seedbased connectivity for off-meds > Seedbased Connectivity for on-meds as predicted by task score off-meds minus task score on-meds.
2. Seedbased connectivity for on-meds > Seedbased Connectivity for on-meds as predicted by task score on-meds minus task score off-meds.

What I’ve done:

Created Firstlevels for off and on meds with seedbased connectivity covariate.

Then I mimicked the Two-Sample Paired T-Test with Covariate design I found at https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind1109&L=FSL&D=0&P=75457 .  My additional covariate is in the form of task score off-meds minus task score on-meds.

However I’m not sure if this design will sufficiently ask the second question due to the way my covariate is coded as off-on task score.  Would anyone be so kind to assist me in understanding if this is the correct way of asking my 2 questions?

Thank you very much for your time,

Dan

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Daniel Cole

Research Assistant - TReAD Lab

Department of Psychology - Emory University

Email: [log in to unmask]

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