Hi Daniel, I'm having a hard time trying to understand the hypotheses (1) and (2) as it seems there's a typo in at least one, and I can't decide what was the intention. Could you double check and post the question again? Thanks Anderson -- Anderson M. Winkler FMRIB / Analysis Group [ Blog <http://brainder.org/> | Twitter <http://twitter.com/AndersonWinkler> ] On 6 August 2015 at 15:14, Cole, Daniel <[log in to unmask]> wrote: > Hello FSLers, > Thanks for taking the time to read this help request. Here is my > situation- > > I have a sample of 17 subjects with on medication and off medication > resting state data. I’d like to use the difference of an on-meds task > score and off-meds task score as covariate. I currently have this > covariate in the form of off task score minus on task score. > > *What I would ideally want to look at is:* > > 1. Seedbased connectivity for off-meds > Seedbased Connectivity for > on-meds as predicted by task score off-meds minus task score on-meds. > 2. Seedbased connectivity for on-meds > Seedbased Connectivity for > on-meds as predicted by task score on-meds minus task score off-meds. > > > *What I’ve done:* > Created Firstlevels for off and on meds with seedbased connectivity > covariate. > > Then I mimicked the Two-Sample Paired T-Test with Covariate design I found > at > https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind1109&L=FSL&D=0&P=75457 > . My additional covariate is in the form of task score off-meds minus task > score on-meds. > > However I’m not sure if this design will sufficiently ask the second > question due to the way my covariate is coded as off-on task score. Would > anyone be so kind to assist me in understanding if this is the correct way > of asking my 2 questions? > > Thank you very much for your time, > Dan > -- > Daniel Cole > Research Assistant - TReAD Lab > Department of Psychology - Emory University > > Email: [log in to unmask] > > ------------------------------ > > This e-mail message (including any attachments) is for the sole use of > the intended recipient(s) and may contain confidential and privileged > information. If the reader of this message is not the intended > recipient, you are hereby notified that any dissemination, distribution > or copying of this message (including any attachments) is strictly > prohibited. > > If you have received this message in error, please contact > the sender by reply e-mail message and destroy all copies of the > original message (including attachments). >