Hello FSLers,
Thanks for taking the time to read this help request. Here is my situation-
I have a sample of 17 subjects with on medication and off medication resting state data. I’d like to use the difference of an on-meds task score and off-meds task score as covariate. I currently
have this covariate in the form of off task score minus on task score.
What I would ideally want to look at is:
- Seedbased connectivity for off-meds > Seedbased Connectivity for on-meds as predicted by task score off-meds minus task score on-meds.
- Seedbased connectivity for on-meds > Seedbased Connectivity for on-meds as predicted by task score on-meds minus task score off-meds.
What I’ve done:
Created Firstlevels for off and on meds with seedbased connectivity covariate.
Then I mimicked the Two-Sample Paired T-Test with Covariate design I found at https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind1109&L=FSL&D=0&P=75457 . My additional covariate is in the form
of task score off-meds minus task score on-meds.
However I’m not sure if this design will sufficiently ask the second question due to the way my covariate is coded as off-on task score. Would anyone be so kind to assist me in understanding
if this is the correct way of asking my 2 questions?
Thank you very much for your time,
Dan