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Dear Karny, Let me explain with some arbitrary values. Depending on your threshold, let's say a voxel is significant if t value > 4. For your schizophrenia patients, maybe all voxels got t value < 4 and thus no 'activation'. Among the controls, maybe some voxels got t value > 4 and thus 'activated'. In one tailed two sample t test [schizophrenia patients - controls], some voxels can be significant if the difference in t value is > 4, e.g. [3 - (-2)] = 5. In this case, this voxel i has t value of 3 in the former group and t value of -2 in the latter group. The resultant becomes > 4. Best, Andy On Mon, Jul 27, 2015 at 4:32 AM, Karny <[log in to unmask]> wrote: > Hi > In one sample t test of schizophrenia patients for a specific contrast we > see activations in a wide range of areas but there's no activation in the > DLPFC. However the controls activated the DLPFC as revealed by a one sample > t test for the same contrast. > But in a two sample t test for the same contrast the analysis revealed a > higher activation of the DLPFC of schizophrenia patients compared to > controls. > Is there a rational explanation for these results? > Thanks... > Karny >