 |
 |
Victoria, Please find below an extract from our macroprolactin SOP. As you can see it has a response to repeat testing within 6 months - no evidence, just a pragmatic approach. Regards, Graham Assay Procedure * Macroprolactin (MPN) analysis is performed on samples with a Prolactin concentration >500U/L, using the Polyethylene Glycol (PEG) precipitation method. * Analysis is performed daily, Monday to Friday. High Prolactins resulted overnight and over the weekend are aliquoted and stored frozen in the MPN rack in the -20 freezer. * Ultra automatically orders a MPN panel within the Immunoassay Master Panel With all resulted Prolactins >500U/L. * Print out the MPN outstanding list and retrieve samples. If an MPN has been done in the last 6 months: If the previous result was positive for MPN: * Perform MPN on the current sample. If the previous result was negative for MPN: * Compare the current and previous Prolactin results. If there is >30% difference between the two results - perform MPN on the current sample. * If there is <30% difference between the current and previous Prolactin results and the previous sample was negative for MPN, add a footnote (library code: NIMPN) to the current Prolactin result as follows: PROLACTIN: Testing of a recent sample from this patient did not demonstrate the presence of Macroprolactin (Prolactin - immunoglobulin complex). Elevated Prolactin is likely to be of the active form. Please contact the laboratory if Macroprolactin testing is required on this sample. Graham Jones Staff Specialist in Chemical Pathology St Vincent's Hospital, Sydney (02) 8382-9160 www.sydpath.com.au From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Clough Victoria (BARKING, HAVERING AND REDBRIDGE UNIVERSITY HOSPITALS NHS TRUST) Sent: Wednesday, 15 July 2015 10:55 PM To: [log in to unmask] Subject: Macroprolactin repeat testing Dear mailbase I'd be interested to hear whether other labs check for macroprolactin in patients with a raised prolactin who've had a previous sample checked and found not to contain macroprolactin. If so, how soon / frequently would you repeat and how did you decide upon this repeat interval? We don't currently repeat the test in these patients but are reviewing our protocol. I will post a summary of any responses I receive. Many thanks Vicky Victoria Clough| Clinical Biochemist Queen's Hospital, Romford Barking, Havering and Redbridge University Hospitals NHS Trust ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Thank you for your co-operation. NHSmail is the secure email and directory service available for all NHS staff in England and Scotland NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and GSi recipients NHSmail provides an email address for your career in the NHS and can be accessed anywhere ******************************************************************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/