SPM does have a built-in mixed-effect model in SPM12, but I have not used it. I believe it combines the 1st and 2nd level analysis. If you want a more traditional lme approach using the 1st-level estimates, then you will need to use R or the LME tool in Freesurfer. Best Regards, Donald McLaren ================= D.G. McLaren, Ph.D. Research Fellow, Department of Neurology, Massachusetts General Hospital and Harvard Medical School Postdoctoral Research Fellow, GRECC, Bedford VA Website: http://www.martinos.org/~mclaren Office: (773) 406-2464 ===================== This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is intended only for the use of the individual or entity named above. If the reader of the e-mail is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you are in possession of confidential and privileged information. Any unauthorized use, disclosure, copying or the taking of any action in reliance on the contents of this information is strictly prohibited and may be unlawful. If you have received this e-mail unintentionally, please immediately notify the sender via telephone at (773) 406-2464 or email. On Sun, Jun 28, 2015 at 2:29 PM, G Ch <[log in to unmask]> wrote: > Dear SPM experts, > > I have fmri data on a group of 21 subjects. Each subject performed tasks > across 8 different conditions. I would like to perform a linear mixed > effects model on the activation levels in a certain area in the 8 different > tasks as well as on the error rates. Does anyone know how can I proceed? > > Best regards, > > George >