Should have mentioned, that using the ResMS approach works in AFNI. In SPM, you need to use [n 1] for the 3rd argument to get an approximation - where n is the number of images in the original model. This corrects for not passing all of the residuals.

On Mon, May 18, 2015 at 4:28 PM, MCLAREN, Donald <[log in to unmask]> wrote:
Alternatively, the square root of the ResMS.img image gives you a good approximation of the smoothness as well.

In the line: 
s_mm=FWHM_est*1.5

1.5 is the voxel size, so if you are using a different voxel size, you should replace this number with the correct number(s).

Best Regards, Donald McLaren
=================
D.G. McLaren, Ph.D.
Research Fellow, Department of Neurology, Massachusetts General Hospital and
Harvard Medical School
Postdoctoral Research Fellow, GRECC, Bedford VA
Website: http://www.martinos.org/~mclaren
Office: (773) 406-2464
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On Mon, May 18, 2015 at 6:32 AM, Katharina Wittfeld <[log in to unmask]> wrote:
Dear Andy,

I've only used Alphasim within the REST toolbox (which had a critical bug) and the current fixed version of it which was released within the DPABI Toolbox.

But the problem of smoothness estimation is the same in preparation to use one of these tools.

I found this website very helpful to keep the residual files for each person:
http://akiraoconnor.org/2010/03/24/keeping-residuals-after-spm-estimation/

To finally estimate the smoothness within a certain ROI I used the SPM function spm_est_smoothness:

% list with residual files
ResI_list = spm_select('List',dir_ResI,'^ResI.*\.img');

% and mask_path is the complete path to your mask defining the ROI

[FWHM_est] = spm_est_smoothness(ResI_list,mask_path)

% be careful which unit you need the smoothness to be in I needed it in mm and had to multiply it by the voxelsize.
s_mm=FWHM_est*1.5

If you don't need the residual files anymore, you can remove them:
    delete('ResI_*.img')
    delete('ResI_*.hdr')

I hope this helps you!

Best, Katharina