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Dear all, we are currently working on a protein that is known to exist in a monomer-dimer equilibrium. At the high concentrations used for crystallisation assays, the dimer is predominant and the monomer practically undetectable. Nevertheless, one of the crystal forms that we have obtained contains the monomeric species, not the dimer. I was wondering if anyone is aware of similar (published) cases, and if the phenomenon as such has been discussed in detail anywhere? I did literature searches but so far couldn't find anything. Any pointers would be much appreciated! Best wishes, Sebastiaan Werten.