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Because the aim is usually to do t testing, you should treat all data the same. If you do one thing to part of the data, and another thing to the rest, then it would be surprising if you didn't find "statistically significant" differences, simply because the data have been treated differently. Best regards, -John On 8 March 2015 at 13:18, 高子凱 <[log in to unmask]> wrote: > Dear SPM users, > > I have two groups for analysis. When doing VBM, is it correct to put all > the rc1* images of two groups to creat a template, or creat a template for > each group? > > Best, > > ZK > > -- > Zih-Kai Kao > Clinical Research Assistant > > Psychiatry Department of Taipei Veterans General Hospital > No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan 11217, > R.O.C. > tel:+886-2-28712121#2912 > fax:+886-2-28742421 >