Dear Daniel, Yes, you can generate a DCM based on simulated data. What DCM gets from the SPM.mat are the stimulus regressors and timing information. This can be fiddly to do yourself – so I would recommend first creating an SPM.mat . You don’t need any fMRI data – click on Batch in the main SPM window, then in the menu at the top, select SPM->Stats->fMRI model specification (Design Only). With your SPM.mat, you can now use spm_dcm_create(‘my_test_dcm’) to create a DCM with simulated data. Best, Peter From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of Daniel Gutierrez Barragan Sent: 04 March 2015 14:27 To: [log in to unmask] Subject: [SPM] DCM on simulated data Hello SPM experts/community, I was wondering if there was a way of feeding a DCM model with simulated data (fMRI BOLD)? I know that the DCM module requires an SPM.mat and VOI.mat (xY, Y) files to be specified, but if I have time courses (disregarding any 1st level analysis and preprocessing) for some predefined seed; the seeds'- geometry, size, and location -, should'n I be able to run DCM with that? I have been browsing through the DCM and VOI routines in order to see what is the essential information that a DCM needs, but I have found lots of variables that are used and found in the VOI files produced from the SPM.mat, which simulated data doesn't have. My question would be if I should: a. Try to create fake SPM.mat? or b. Modify which DCM routine and variables? In advance I greatly appreciate your help. Best regards, -- Daniel Gutiérrez Barragán CIMeC PhD. Student, CBS - University of Trento.