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We were discussing Short Synacthen testing a few days ago, especially in the light of the paper comparing responses and measuring by GCMS and 5 different immunoassays El-Erhan et al., Clinical Endocrinology (2013) 78, 673-680 which suggests that currently used cut-offs (550 - 580) may be misclassifying some normal people as deficient. Our endocrinologists are suggesting decreasing the cut-off level. What cortisol levels do you take as adequate basal and stimulated response, and on what equipment are you measuring it? I'm happy to collate responses. Many Thanks Michael Dr. C . M. Colley Consultant Chemical Pathologist Great Western Hospital Swindon SN3 6BB ________________________________ Great Western Hospitals NHS Foundation Trust Great Western Hospital Marlborough Road Swindon SN3 6BB Tel 01793 60 40 20 http://www.gwh.nhs.uk Register to become a member of the Trust at https://members.gwh.nhs.uk This message and any files transmitted with it are confidential and intended solely for the individual(s) addressed. If you believe you have received this e-mail in error, disclosing, copying, distributing or retaining this message, or any part of it, is strictly prohibited; please notify the sender immediately and delete it from your system. Any views or opinions presented are solely those of the author and do not necessarily represent those of Great Western Hospitals NHS Foundation Trust. All messages sent by the Trust are checked for viruses but this does not, and cannot, guarantee that a virus has not been transmitted. The Trust accepts no liability for any damage caused by any virus transmitted with this e-mail. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/