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MEDICAL: DISEASES :
MEDICAL: RFSEARCH :
MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUG EFFECTIVENESS:
Antibiotic Breakthrough May Signal the End of Drug-Resistant Superbugs
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Antibiotic Breakthrough May Signal the End of Drug-Resistant Superbugs
Catharine Paddock PhD
Medical News Today (MNT)
http://www.medicalnewstoday.com/articles/287745.php
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Scientists have come across a potential game-changer in the fight against
drug-resistant superbugs - a new class of antibiotic that is resistant to
resistance. Not only does the new compound - which comes from soil
bacteria - kill deadly superbugs like MRSA, but also - because of the way
it destroys their cell wall - the pathogens will find it very difficult to
mutate into resistant strains.
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Kim Lewis, a microbiologist and professor at Northeastern University in
Boston, MA, and colleagues report their discovery in the journal Nature.
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Many of the antibiotics in use today were discovered decades ago, and
since then, microbes have evolved into resistant strains that do not
succumb to them.
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For instance, according to the World Health Organization (WHO), in 2012,
there were about 450,000 new cases of multidrug-resistant tuberculosis
(MDR-TB) worldwide. And extensively drug-resistant tuberculosis (XDR-TB)
has been identified in 92 countries.
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snip
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This alarming scenario - coupled with the fact there are hardly any new
antibiotics in the pipeline - led the WHO recently to warn we are
approaching a "post-antibiotic era" where people could die from ordinary
infections and minor injuries.
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snip
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Teixobactin breaks down the bacterial cell wall - the pathogen's key
defence against attack. The researchers believe this means the microbe can
mutate all it likes, but its cell walls will always be its Achilles heel.
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Prof. Lewis says, "Teixobactin's dual mode of action and binding to
non-peptidic regions suggest that resistance will be very difficult to
develop."
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He and his colleagues found that repeated exposure to the drug did not
produce any resistant mutations in Staphylococcus aureus or Mycobacterium
tuberculosis, the bacterium that causes most cases of TB.
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They conclude: "The properties of this compound suggest a path towards
developing antibiotics that are likely to avoid development of
resistance."
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The complete article may be read at the URL above.
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A new antibiotic kills pathogens without detectable resistance
Losee L. Ling,
Tanja Schneider,
Aaron J. Peoples,
Amy L. Spoering,
Ina Engels,
Brian P. Conlon,
Anna Mueller,
Till F. Scherle,
Dallas E. Hughes,
Slava Epstein,
Michael Jones,
Linos Lazarides,
Victoria A. Steadman,
Douglas R. Cohen,
Cintia R. Felix,
K. Ashley Fetterman,
William P. Millett,
Anthony G. Nitti,
Ashley M. Zullo,
Chao Chen
& Kim Lewis
Affiliations
Contributions
Corresponding author
Nature
(2015)
doi:10.1038/nature14098
Received
29 July 2014
Accepted
19 November 2014
Published online
07 January 2015
" Here we report a new antibiotic that we term teixobactin, discovered in
a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis
by binding to a highly conserved motif of lipid II (precursor of
peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We
did not obtain any mutants of Staphylococcus aureus or Mycobacterium
tuberculosis resistant to teixobactin. The properties of this compound
suggest a path towards developing antibiotics that are likely to avoid
development of resistance."
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14098.html
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