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Just set up a full factorial design in SPM. You can specify each factor and the interaction if you want in the model. If there is no interaction, then you just want the two main effects in the model. Best Regards, Donald McLaren ================= D.G. McLaren, Ph.D. Research Fellow, Department of Neurology, Massachusetts General Hospital and Harvard Medical School Postdoctoral Research Fellow, GRECC, Bedford VA Website: http://www.martinos.org/~mclaren Office: (773) 406-2464 ===================== This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is intended only for the use of the individual or entity named above. If the reader of the e-mail is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you are in possession of confidential and privileged information. Any unauthorized use, disclosure, copying or the taking of any action in reliance on the contents of this information is strictly prohibited and may be unlawful. If you have received this e-mail unintentionally, please immediately notify the sender via telephone at (773) 406-2464 or email. On Tue, Dec 30, 2014 at 1:53 PM, Manish Dalwani < [log in to unmask]> wrote: > Hello SPM'ers, > > Can someone please point me to a link on how to set up 2x2 design where I > can test for interactions (and main effects in case of no interaction)? > > Best, > Manish Dalwani >