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Although it shouldn't be needed, did you make sure the origin of T1 image was the same as the TPM maps? Best Regards, Donald McLaren ================= D.G. McLaren, Ph.D. Research Fellow, Department of Neurology, Massachusetts General Hospital and Harvard Medical School Postdoctoral Research Fellow, GRECC, Bedford VA Website: http://www.martinos.org/~mclaren Office: (773) 406-2464 ===================== This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is intended only for the use of the individual or entity named above. If the reader of the e-mail is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you are in possession of confidential and privileged information. Any unauthorized use, disclosure, copying or the taking of any action in reliance on the contents of this information is strictly prohibited and may be unlawful. If you have received this e-mail unintentionally, please immediately notify the sender via telephone at (773) 406-2464 or email. On Thu, Jan 29, 2015 at 6:24 AM, Pauline Bezivin < [log in to unmask]> wrote: > Dear SPM-experts, > > I would like to segment anatomical scans of adolescents but I have some > issues using the SPM12 segmentation procedure. On the figure attached to > this email, you can see an example of this misclassification (more often in > the frontal part of the brain). It seems there is a misregistration between > the T1 image and the TPM (we use the default one or our own adolescent TPM > based on a subsample of subjects without success). I tried also to change > different options: affine regularisation and bias regularisation options, > but nothing was concluding. Did you encounter this kind of problem and did > you find a way to fix it? > > Thanks, > > Pauline Bezivin > PhD Student >