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Dear Helmut, If I am understanding this correctly, I should do 1. Run segmentation in SPM and select "East Asian" in segmentation. 2 Run Dartel as usual (select grey and white images) and hit run. 3. Replace the TPM.nii file with my template.nii file and Run normalize to MNI space. How about labels_Neuromorphometrics.nii/xml file? I don't have these files for Chinese brain template. Is this ok? 4. After running the statistical analysis, will I be able to know which area has significance (since this group is not in MNI space, instead it is in Chinese brain 56 template space). I got this template from loni's website. Thanks for any input. Miao Helmut Nebl <[log in to unmask]>于2014年12月6日星期六写道： > Dear Miao, > > It should be sufficient to > 1) replace the TPMs / templates or to change the corresponding paths. The > normalised images generated during segmentation would then be in the space > of these priors/templates, so instead of MNI it would be "Chinese atlas > space". > 2) adjust some of the restraining parameters (like the East Asian settings > for affine regularisations), which is going to depend on the templates. > > However, as far as I can see there are no TPMs, so the T1 templates are > not that useful. If you have a very large data set you could try to create > your own TPMs of course, starting with these T1 templates (but you would > probably create your own then). > > Best, > > Helmut > >