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Brilliant. Should do wonders for hypertension then. Kev > On 23 Dec 2014, at 18:21, Ted Harding <[log in to unmask]> wrote: > > Tom Jefferson has nicely widened the efficacity of a well-established > folk medicine, already renowned for its beneficial effects on mental > and emotional function, namely: Salisternuvir. > > Etymology (from Latin) > "Salis": salt > "Ternum": pinch > "vir": Obligatory suffix required by Regulatory Authorities > > Well done, Tom. > > And Season's Greetings to all! > Ted. > > On 23-Dec-2014 07:40:23 Tom Jefferson wrote: >> The label says: >> >> "Overall, subjects receiving RAPIVAB 600 mg experienced alleviation >> of their combined influenza symptoms a median of 21 hours sooner >> than those receiving placebo. The median time to recovery to normal >> temperature (less than 37°C) in the 600 mg group was approximately >> 12 hours sooner compared to placebo." >> >> "There is no evidence for efficacy of RAPIVAB in any illness caused >> by agents other than influenza viruses. Serious bacterial infections >> may begin with influenza-like symptoms or may coexist with or occur >> as complications during the course of influenza. RAPIVAB has not been >> shown to prevent such complications." >> >> It is also worth having a look at the press release. >> >> http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427755.htm >> >> noting the irrelevance of the opening CDC-like statement about >> hospitalisations for a drug which does not have evidence of affecting >> hospitalizations, complications etc. >> >> The harms bit is generic with gastrointestinal harms (like the other two >> NIs) and the mystification of psychiatric effects (which could be be >> confused with influenza symptoms and viceversa). We labelled these >> "compliharms" in our review. >> >> We have shown that in prophylaxis (where there is no influenza >> interference) there is increased risk of neuropsychiatric harms. >> >> All in all this means that the FDA press releases are to be taken with many >> pinches of salt. >> >> >> Tom. >> >> On 23 December 2014 at 08:29, Tom Jefferson <[log in to unmask]> wrote: >> >>> No, the same as Tamiflu and Zanamvir. >>> >>> The drugs have a central action probably acting on the hypothalamus and >>> bringing fever down. Their in vitro effect on influenza viruses does not >>> appear to have a practical impact in vivo. >>> >>> There is no other credible evidence of any other effect on any other >>> outcomes. >>> >>> I notice that there is nothing on harms. >>> >>> Happy Xmas to you all, >>> >>> Tom. >>> >>> On 22 December 2014 at 22:48, write words <[log in to unmask]> wrote: >>> >>>> Is this clinically relevant? >>>> >>>> From the press release >>>> <http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427755.htm> >>>> : >>>> >>>> Rapivab's efficacy was established in 297 participants with confirmed >>>> influenza who were randomly assigned to receive Rapivab 300 milligrams >>>> (mg), Rapivab 600 mg or placebo. Overall, participants receiving Rapivab >>>> 600 mg had their combined influenza symptoms alleviated 21 hours sooner, on >>>> average, than those receiving placebo, which is consistent with other drugs >>>> in the same class. Those receiving Rapivab 600 mg also recovered to normal >>>> temperature approximately 12 hours sooner compared to placebo. Supportive >>>> trials confirmed these findings. However, efficacy could not be established >>>> in patients with serious influenza requiring hospitalization. >>>> >>>> >>>> >>>> -Christie >>>> >>>> >>> >>> >>> -- >>> Dr Tom Jefferson >>> Medico Chirurgo >>> GMC # 2527527 >>> >> >> >> >> -- >> Dr Tom Jefferson >> Medico Chirurgo >> GMC # 2527527 > > ------------------------------------------------- > E-Mail: (Ted Harding) <[log in to unmask]> > Date: 23-Dec-2014 Time: 18:21:40 > This message was sent by XFMail > -------------------------------------------------