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In addition to some fat skin etc., the tpm for class 5 contains some of the major vessels: MCA, some of transverse sinus, sagittal sinus, some of Circle of Willis, and in SPM12 the straight sinus. There is actually quite a bit of difference between TPM,5 in SPM12 and the one form “new segmentation” in SPM8. I have tried to add a vessel only class based on a MP2RAGE with and without contrast. But this is a tricky class to fit as the intensity will wary greatly depending on the angle between B0 and the flow. I would be great if John could share some details about how these templates were created.

Best

Torben

P.S. in the attached figure the intensity range was reduced to [0 0.5], and the SPM12 version is shown on top.