Hi everyone, I want to compute intracranial volumes (ICV) on T1 images. I use the "New segment" procedure and then apply the following script that I found on this forum: V = spm_vol(spm_select(Inf,'Image')); Vols = zeros(numel(V),1); for j=1:numel(V), tot = 0; for i=1:V(1).dim(3), img = spm_slice_vol(V(j),spm_matrix(... [0 0 i]),V(j).dim(1:2),0); img = img(isfinite(img)); % <-- exclude non-finite values tot = tot + sum(img(:)); end; voxvol = abs(det(V(j).mat))/100^3; % volume of a voxel, in litres Vols(j) = tot*voxvol; end I do not understand why but I sometimes have slightly different results if I put only one image there (e.g. one c1 image), or the images of 6 subjects at one As an example, for the c1 volumes, I get these volumes for 6 subjects (only c1 images) if I put them all together: 0,748791232277067 0,566458297542124 0,694005878830069 0,804684337578292 0,497836206898500 0,813398758282534 But if I put only the 5th one alone, I get this volume 0,541700962208066 Any idea why ? Thanks a lot, Josselin Houenou