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Hi, Niels is right - I completely missed the -s option in your commands - my apologies. In this case it is quite unusual to see this kind of problem. Have you checked to see what the initial registration is like? If this is poor then it could cause this problem. The other situation that might be a problem is if there is a lot of atrophy in the accumbens and it cannot make the mesh thin/small enough. It would be useful to see the image in this case, so please upload an example to: https://oxfile.ox.ac.uk/oxfile/work/extBox?id=68312615463381F4C All the best, Mark > On 28 Nov 2014, at 09:06, Nele De Witte <[log in to unmask]> wrote: > > Hi Mark and Niels, > > Thank you for the response. I indeed already ask for the nucleus accumbens (and I also tried asking for the amygdala, but that also didn't work for these participants). Do you have any other ideas then, Mark? > > Niels, I will mail you the file of one participant. Thank you so much for your time! > > Sincere regards, > Nele