Ella,
In principle connectivity can be extracted from BOLD and ASL data, but BOLD is generally better since it has a higher temporal resolution. However, ASL gives you the ability to quantify absolute perfusion so you can also examine physiological changes between baseline and intervention. In theory something like a dual-echo method might give you both bits of information, but that might take some more work.
Michael
On 15 Oct 2014, at 10:44, Ella Hinton <[log in to unmask]<mailto:[log in to unmask]>> wrote:
Hi FSLers,
I have a question - I am looking into conducting resting brain scans in order to measure the effects of an intervention on appetite, so I am particularly interested in reward and satiety pathways including OFC, DLPFC, anterior piriform cortex, as well as striatum, amygdala and nucleus accumbens.
When would you advise using a resting BOLD scan, and when would you use a resting pCASL scan?
Can either be used to investigate connectivity?
Thanks for any advice,
best wishes
Ella
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Michael Chappell MEng DPhil
W: http://www.ibme.ox.ac.uk/qubic
T: +44 1865 617657
Associate Professor, Institute of Biomedical Engineering, University of Oxford.
http://www.ibme.ox.ac.uk
Director of Training, EPSRC-MRC CDT in Biomedical Imaging
http://www.onbi.ox.ac.uk
Governing Body Fellow, Wolfson College, Oxford.
http://www.wolfson.ox.ac.uk
Research Fellow, FMRIB Centre
http://www.fmrib.ox.ac.uk
