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Again, I appreciate all of your suggestions. I have tried many of them and I am excited to report that I have had great success with the Crank-2 Enhanced EP pipeline in ccp4 as recommended by Navraj Pannu. Even without my partial rosetta model, Crank2 was able to build a model that covers ~85% of my structure- much better than my partial rosetta model that only covers ~50%. Because I only gave crank2 my iodide dataset and my sequence, it was encouraging to see that the Crank2 model aligns quite well with my partial rosetta model. I hope that others who have datasets with weak anomalous signal give crank2 a try! Thanks again, Gabriel On Oct 13, 2014, at 4:06 PM, Gabriel Salzman <[log in to unmask]> wrote: > I appreciate all of your responses and I will give your recommendations a try! > > > Thanks, > Gabriel > > > On Oct 13, 2014, at 1:50 PM, Kay Diederichs <[log in to unmask]> wrote: > >> Hi Gabriel, >> >> what you want to do is called MRSAD - use the partial MR model to find the sites, combine the phase information, and complete the model. There are hits with the keyword MRSAD if you search on phenix-online.org >> >> HTH, >> Kay >