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Great I put all blipup and then blipdown in one single 4D file and I get eddy: msg=These data do not support least-squares resampling I do have 132 (66*2) I try to separate bilpup and bilpdonw in the --imain argument (like in topup) but eddy does not parse it correctly --imain=4D_dwiAP.nii.gz,4D_dwiPA.nii.gz Image Exception : #22 :: ERROR: Could not open image 4D_dwiAP.nii.gz,4D_dwiPA May be the option is not fully operational ? Or I have a setting problem I did the top on the B0 with -1 0 0 0.050 -1 0 0 0.050 -1 0 0 0.050 -1 0 0 0.050 -1 0 0 0.050 -1 0 0 0.050 1 0 0 0.050 1 0 0 0.050 1 0 0 0.050 1 0 0 0.050 1 0 0 0.050 1 0 0 0.050 the index for the 4D is then 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 5 5 5 6 7 7 7 7 7 7 7 7 7 7 7 7 7 8 8 8 8 8 8 8 8 8 8 8 8 8 9 9 9 9 9 9 9 9 9 9 9 9 9 10 10 10 10 10 10 10 10 10 10 10 10 10 11 11 11 11 11 11 11 11 11 11 11 11 11 12 Many thanks Le 05/09/2014 14:27, Jesper Andersson a écrit : > Oh, > > you’re right. I has managed to make it’s way into the release already then ;-) > > So, that would be the way to do it. Make sure that you have duplicated all diffusion directions with opposing PE-directions and use —resamp=lsr. > >> what is then the option --resamp lsr in eddy ? >> >> For the connectom data their acquired 288*2 raw data but the preprocess data have only 288 volume so I guess they did a pairwise restoration... no ? may be they have a special releas of eddy ? > When the pipeline for the HCP was finalised we didn’t yet have the lsr option, so the HCP data is actually resampled with the jac option and then simply averaged. > > Jesper > >> Many thanks