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FSL folks, So the VBM wiki talks about making sure that one has equal parts controls and patients when doing early VBM steps. I understand the rationale for this in terms of making an unbiased template. However, are you supposed to always keep things like this (i.e. completely equal, number-wise) for the entirety of the VBM analysis? It seems like you could add back the "extra" subjects in whatever group at step 3 and beyond. Is that correct, or are you completely limited by whatever group has the lowest 'N'? Thanks -- Paul Beach DO/PhD candidate - Year VI Michigan State University - College of Osteopathic Medicine - Neuroscience Program - MSU *Co*gnitive and *Ge*riatric *N*eurology *T*eam (*CoGeNT*)