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Hi,

It's hard to know what's going wrong here without knowing a bit more about the exact commands you and running and the nature of your cost weighting image.  Am I correct in understanding that you can get good registrations between individual subjects using the weighting, but not between a subject and the template?  Is you weighting image in the input or reference space (or both)?  Is this only with flirt or with fnirt or with both?  Does you weighting image consist of zeros and ones, or is there more to it?  Do you initialise with a non-weighting registration?  What exact registration cause the result that you attached?

If you can provide answers to these questions, and any other information that you think might be relevant, then we can hopefully help some more.

All the best,
Mark



On 30 Jul 2014, at 15:11, Ricardo Magalhaes <[log in to unmask]> wrote:

Dear FSL experts,

I am working on the registration of rodent FA maps to a version of the recently released Waxholm template, by adapting the TBSS scripts, with success so far. 

My issue came up when I was looking to improve the registration of the main white matter tracts by using the weight arguments (-refweight -inweight) of the the flirt function. The logic is that by giving the main WM tracts (which is what we are interested), as defined in the FA map, a higher weight in the cost function I would have a better registration of them. 

I have been successful in registering images to the template using both flirt and fnirt, and I managed to slightly improve the co-register of different subjects to each other using the -refweight and -inweight options of flirt. But when I try to register one of the subjects to the template using either or both of the options the results are always a distorted blur you can find in the attached file. 

Am I just miss understanding the usage of the weight options or forgetting to consider something?

all the best,

--
Ricardo Magalhães, 
Neurosciences Research Domain (NeRD)
ICVS/3B´s Laboratório Associado
PT Government Associate Laboratory

University of Minho, Campus de Gualtar
4710-057 Braga, Portugal

(+351 253604925)
<flirtrefweight.pdf>