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Dear all, I am trying to work in native space instead of in MNI space. I would like to transform all my 4D functional data matrices of the same subject to fit the anatomical data (not from the same session). In the next step I read the nifti into Matlab and use it as a data matrix, so changes of information in the header cannot help me - the transformation should apply to the data itself. The problem is that my anatomy is in 1x1x1mm resolution, while my functional scan is 3x3x3.3 I would like to keep the original resolution in order to avoid memory issues (right now everything I am trying fails because the data matrix ends up being too large). This appears to be something very basic, but somehow I found it easier to transform to MNI than to keep the native resolution in the right orientation. Every help will be much appreciated! Thank you very much in advance, Francesca