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Hi Salil, Yes, sure. Have a look at the paired t-test: http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/GLM#Single-Group_Paired_Difference_.28Paired_T-Test.29 All the best, Anderson On 22 August 2014 15:29, Salil Soman <[log in to unmask]> wrote: > Dear List Members, > > Is there a way to perform tbss longitudinally? I have a group that had an > intervention (half got intervention A and those who got intervention B) > with 30 direction dti both pre and post intervention. I would like to see > what significantly different changes occurred within groups and between > groups. > > Thank you for your time and consideration. > > Best wishes, > > Salil >