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Hi Donald, thanks for the answer and sorry for the late reply. In deed between-session effects are not of interest. I'm not sure if I understood you correctly: Do I need to pre-process every session for every subject seperately? In other words, do I need to have three different mean functional images (one per session) for every subject for the first level model? Because up to now I created *one* mean image over all sessions per subject by using three session tabs per subject in the slice-timing and realignment. greetings David 2014-07-03 15:21 GMT+02:00 MCLAREN, Donald <[log in to unmask]>: > Put all 3 sessions into your first level model, create a single contrast > across the three sessions, and then use this contrast in the 2nd-level > model. This assumes that you don't care about any session effects or that > you plan to ignore the session effect. This may or may not be good > depending on your question and study design. > > Best Regards, Donald McLaren > ================= > D.G. McLaren, Ph.D. > Research Fellow, Department of Neurology, Massachusetts General Hospital > and > Harvard Medical School > Postdoctoral Research Fellow, GRECC, Bedford VA > Website: http://www.martinos.org/~mclaren > Office: (773) 406-2464 > ===================== > This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED > HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is > intended only for the use of the individual or entity named above. If the > reader of the e-mail is not the intended recipient or the employee or agent > responsible for delivering it to the intended recipient, you are hereby > notified that you are in possession of confidential and privileged > information. Any unauthorized use, disclosure, copying or the taking of any > action in reliance on the contents of this information is strictly > prohibited and may be unlawful. If you have received this e-mail > unintentionally, please immediately notify the sender via telephone at > (773) > 406-2464 or email. > > > On Thu, Jul 3, 2014 at 9:17 AM, David Hofmann <[log in to unmask]> > wrote: > >> Hi @all, >> >> I have some fMRI data consisting of 30 testsubject where each subject has >> been tested three times. So there are multiple sessions. >> >> Now I don't know how to combine/merge those three session per subject in >> order to do my 2nd-level analysis. Can someone give me some tips how to >> proceed in such a case? >> >> greetings >> >> David >> >> >> >> >>