Experts,

I would like to compare the substrate binding site of two homologous
proteins. Based on crystal structures it is clear that the substrate
binding site of protein A is more solvent exposed then protein B.

Is there a way to measure the solvent exposure of the substrate in protein
A and B? Or perhaps you have an additional suggestion for making a
structural comparison (besides what seems obvious...noting the differences
in non-covalent interactions)?

Thanks,
Jeff