Dear Colleagues Should numbers-needed-to-harm require a confidence interval? And if the adverse event rates from which the NNHs are calculated have a confidence interval crossing the line of no effect and the NNH have the same, how do you interpret the results? I have a study that states: Because of the large and non-significant confidence intervals around the steroid injection adverse event rates, confidence intervals were not reported for the NNH, as proposed by McQuay and Moore The study is: Gaujoux-Viala C, et al. Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trials. Ann Rheum Dis 2009;68(12):1843-9. I look forward to your replies Regards Mark Mark Ayson MBChB DPH Research Advisor, ACC Tel (04) 816-6386 / Ext 46386 ACC / Research / Justice Centre - Level 7 PO Box 242 / Wellington 6011 / New Zealand / www.acc.co.nz ACC cares about the environment - please don't print this email unless it is really necessary. Thank you. -------------------------------------------------------------------------------------- Disclaimer: "This message and any attachments may contain confidential and privileged information. If you believe you have received this email in error, please advise us immediately by return email or telephone and then delete this email together with all attachments. If you are not the intended recipient, you are not authorised to use or copy this message or any attachments or disclose the contents to any other person. " --------------------------------------------------------------------------------------