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Hello Jochen, > I tried to normalise several subjects and get differences in the > dimensions of my image (73x89x42 vs. 73x88x41) and some differences in > the origin. I checked bounding box and voxel size and the rest of the > normalisation procedure and there should be no difference between the > preprocessing steps, except that one image has been preprocessed in > spm5, the other one in spm8. What is going wrong? I would like to do > second level analysis which is not possible because of the different > dimensions. How can I fix the problem? I think by stating "there should be no difference except one was spm5 and the other was spm8", you underestimate the rate of scientific progress ;) But more seriously, the difference comes from how the bounding box is calculated, which obviously changed between versions. As mentioned before, mixing spm versions is not recommended, for exactly the kind of issues you encounter (actually, you are lucky because the difference in your case is obvious while it may not be that obvious, but still substantial, for other updates/bugfixes). If you seriously want to go on with this approach, you could specify the bounding box explicitly, which can be done in different ways depending on how you achieved normalization. Cheers, Marko -- ____________________________________________________ PD Dr. med. Marko Wilke Facharzt für Kinder- und Jugendmedizin Leiter, Experimentelle Pädiatrische Neurobildgebung Universitäts-Kinderklinik Abt. III (Neuropädiatrie) Marko Wilke, MD, PhD Pediatrician Head, Experimental Pediatric Neuroimaging University Children's Hospital Dept. III (Pediatric Neurology) Hoppe-Seyler-Str. 1 D - 72076 Tübingen, Germany Tel. +49 7071 29-83416 Fax +49 7071 29-5473 [log in to unmask] http://www.medizin.uni-tuebingen.de/kinder/epn/ ____________________________________________________