Hi, It looks like it has failed to created a necessary image. Check to see if any of the initial steps have failed, such as registration or segmentation. I suspect that the problem will lie there, but we will need more information in order to help solve the problem. All the best, Mark On 24 Apr 2014, at 15:24, wyey0755 <[log in to unmask]<mailto:[log in to unmask]>> wrote: I am trying to run sienax module on T1 dataset. But it shows me following error. Any help will be appreciated. Cannot open volume I_stdmaskbrain_pve_1 for reading! Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_pve_1_segperiph dc: stack empty dc: stack empty dc: stack empty dc: stack empty Cannot open volume I_stdmaskbrain_pve_0 for reading! Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_pve_0_segvent dc: stack empty dc: stack empty dc: stack empty dc: stack empty Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_pve_1 dc: stack empty dc: stack empty dc: stack empty dc: stack empty Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_pve_2 dc: stack empty dc: stack empty dc: stack empty dc: stack empty Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_seg terminate called after throwing an instance of 'RBD_COMMON::BaseException' Aborted (core dumped) Image Exception : #22 :: ERROR: Could not open image I_render Error in slicer input, exiting... Cannot open grIa.png for reading Segmentation fault (core dumped) /bin/rm: cannot remove : No such file or directory Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_pve_1_segperiph terminate called after throwing an instance of 'RBD_COMMON::BaseException' Aborted (core dumped) Image Exception : #22 :: ERROR: Could not open image I_stdmaskbrain_pve_0_segvent terminate called after throwing an instance of 'RBD_COMMON::BaseException' Aborted (core dumped) Image Exception : #22 :: ERROR: Could not open image I_periph_render Error in slicer input, exiting... Cannot open grIa.png for reading Segmentation fault (core dumped) Image Exception : #22 :: ERROR: Could not open image I_vent_render Error in slicer input, exiting... Cannot open grIa.png for reading Segmentation fault (core dumped) /bin/rm: cannot remove : No such file or directory Finished. The SIENAX report can be viewed by pointing your web browser at: file:/home/wyey0755/Downloads/fslvbmtest/image/T1/20140420_1410078HRfMRI9s008a1001_sienax/report.html Estimated normalised brain volume (NBV) = 2.50 Thank you.