Dear Deng, you need to find out the coordinates in voxel space by: inv(SPM.VM.mat)*[-22 -10 52 1]' which gives: 57 59 63 1 when assuming that SPM.VM.mat looks like this: -2 0 0 92 0 2 0 -128 0 0 2 -74 0 0 0 1 Then you can extract the betas using: spm_get_data(SPM.Vbeta,[57 59 63]') Regards, Thilo On Wed, 2014-03-05 at 13:04 +0000, SUBSCRIBE SPM Deng Wang wrote: > Dear all, > > Does anyone know how to extract beta weights for a specific coordinate (for example MNI: x=-22;y=-10;z=52 or Talairach: x=-22;y=-16;z=49) in SPM8? I would appreciate it if you could reply to me. > > Best, > Deng